Amphetamine induced endogenous opioid release in the human brain detected with [11C]carfentanil PET: Replication in an independent cohort
نویسندگان
چکیده
Complete List of Authors: Mick, Inge; Imperial College, Myers, Jim; Imperial College, Stokes, Paul; King's College, ; Imperial College, Erritzoe, David; Imperial College, Colasanti, Alessandro; Imperial College, ; King's College, ; Imanova Ltd., Bowden-Jones, Henrietta; National Problem Gambling Clinic, Clark, Luke; University of Cambridge, Gunn, Roger; Imperial College, ; Imanova Ltd., Rabiner, Eugenii; King's College, ; Imanova Ltd., Searle, Graham; Imanova Ltd., Waldman, Adam; Imperial College, Parkin, Mark; King's College, Brailsford, Alan; King's College, Nutt, David J; Imperial College, Lingford-Hughes, Anne; Imperial College,
منابع مشابه
Amphetamine induced endogenous opioid release in the human brain detected with [¹¹C]carfentanil PET: replication in an independent cohort.
This study aimed to replicate a previous study which showed that endogenous opioid release, following an oral dose of amphetamine, can be detected in the living human brain using [11C]carfentanil positron emission tomography (PET) imaging. Nine healthy volunteers underwent two [11C]carfentanil PET scans, one before and one 3 h following oral amphetamine administration (0.5 mg/kg). Regional chan...
متن کاملEndogenous opioid release in the human brain reward system induced by acute amphetamine administration.
BACKGROUND We aimed to demonstrate a pharmacologically stimulated endogenous opioid release in the living human brain by evaluating the effects of amphetamine administration on [(11)C]carfentanil binding with positron emission tomography (PET). METHODS Twelve healthy male volunteers underwent [(11)C]carfentanil PET before and 3 hours after a single oral dose of d-amphetamine (either a "high" ...
متن کاملEffects of amphetamine on the human brain opioid system – a positron emission tomography study
Studies in rodents have shown that psychostimulant drugs such as cocaine and amphetamine cause endorphin release in the brain reward system. There is also evidence for the involvement of the opioid system in human psychostimulant dependence. The acute effects of an i.v. psychostimulant drug on the brain opioid system, however, have not yet been investigated in humans. We hypothesized that an i....
متن کاملMu Opioid Receptor Binding Correlates with Nicotine Dependence and Reward in Smokers
The rewarding effects of nicotine are associated with activation of nicotine receptors. However, there is increasing evidence that the endogenous opioid system is involved in nicotine's rewarding effects. We employed PET imaging with [11C]carfentanil to test the hypotheses that acute cigarette smoking increases release of endogenous opioids in the human brain and that smokers have an upregulati...
متن کاملFeeding Releases Endogenous Opioids in Humans.
The endogenous opioid system supports a multitude of functions related to appetitive behavior in humans and animals, and it has been proposed to govern hedonic aspects of feeding thus contributing to the development of obesity. Here we used positron emission tomography to investigate whether feeding results in hedonia-dependent endogenous opioid release in humans. Ten healthy males were recruit...
متن کامل